| 維他命D和薑黃素結合物有益腦部健康 |
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維他命D和薑黃素結合物有益腦部健康 一份新的研究報告指出由鬱金根提煉出的維他命D和薑黃素,結合物可以提升免疫系統的功能，並可以幫助清除與阿茲罕默症有關的蛋白質斑塊。一份近期在阿茲罕默症期刊發表的研究資料表示，單一使用維他命D3或與合成或天然薑黃素一起使用可以促進免疫系統已達到保護腦部預防乙型澱粉樣蛋白。腦細胞損壞或死亡與乙型澱粉樣蛋白堆積物有關係，進而導致認知功能的退化並引發阿茲罕默症。而阿茲罕默症則是一種最常見的失智症，在全世界有1千3百萬的人罹患此症。在人體免疫系統中，單核球細胞轉變成巨蝕細胞可以提升人體的免疫系統功能，而在阿茲罕默症的病人中因為斑塊的堆積所以沒有這樣的轉化。研究發現薑黃素促進乙型澱粉樣蛋白與巨蝕細胞的結合，而維他命D則可以刺激巨蝕細胞對乙型澱粉樣蛋白的吸收。近來有越來越多的研究報告顯示維他命D不足與心血管疾病，糖尿病，骨質疏鬆症，憂鬱症和牙周病有關係。 Vit D-curcumi n combo offers brain health potential A combination of vitamin D3 and curcumin, from tumeric, may boost the immune system, and help it clear the protein plaques linked to Alzheimer’s, says a new study. The new data, published in the Journal of Alzheimer's Disease, may lead to new approaches in preventing Alzheimer's by using vitamin D3 alone or in combination with natural or synthetic curcumin to boost the immune system in protecting the brain against beta-amyloid. The build-up of plaque from beta-amyloid deposits is associated with an increase in brain cell damage and death from oxidative stress. This is related to a loss of cognitive function and an increased risk of Alzheimer's, the most common form of dementia and currently affects over 13 million people worldwide. The direct and indirect cost of Alzheimer care is over $100 bn (€81 bn) in the US, while direct costs in the UK are estimated at £15 bn (€22 bn). "We hope that vitamin D3 and curcumin, both naturally occurring nutrients, may offer new preventive and treatment possibilities for Alzheimer's disease," said Dr Milan Fiala from the University of California Los Angeles (UCLA). Study details Monocyte cells, which transform into macrophages and in turn boost the immune system, were isolated from the blood samples were taken from nine Alzheimer's patients, one patient with mild cognitive impairment and three healthy control subjects. The macrophages were then incubated with beta-amyloid, vitamin D3 and natural or synthetic curcumin. The synthetic curcuminoid compounds were developed in the laboratory of John Cashman at the Human BioMolecular Research Institute. The naturally occurring curcumin was found to be poorly absorbed, making it less effective than the synthetic curcuminoids, said the researchers. “We think some of the novel synthetic compounds will get around the shortcomings of curcumin and improve the therapeutic efficacy,” said Cashman. The curcuminoids were found to enhance binding of beta-amyloid to macrophages, and that vitamin D could strongly stimulate the uptake and absorption of beta-amyloid in macrophages in most of the patients. Previous research by same scientists found that there are two types of Alzheimer's patients: Type 1 patients, who respond positively to curcuminoids, and Type II patients, who do not. This depends on the genes MGAT III and TLR-3 that are associated with the immune system's ability to better ingest amyloid beta, said the researchers. "Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient," said Fiala. The UCLA researchers stressed that the research is still in its early stages and that no doses of either compound can be recommended at this point. They noted that larger vitamin D and curcumin studies with more patients are planned. The need for D A growing number of studies have linked deficiency of vitamin D to increased risks of cardiovascular diseases, diabetes, osteoporosis, depression, and periodontal disease, all of which have been linked to some degree to increased risks for dementia. 資料來源: Journal of Alzheimer’s Disease
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