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| Omega-3 DHA 可以幫助健康成年人的記憶力 |
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Omega-3 DHA 可以幫助健康成年人的記憶力,非阿茲海默症患者一份由Martek做的研究結果顯示，每日攝取omega -3 DHA可以幫助老年人的記憶力還有心臟健康。“在我們的研究中，健康但有記憶力困擾的自願者服用海藻DHA膠囊持續六個月後，在測試學習還有記憶表現都有顯著的改變，比服用安慰劑的自願者有兩倍的改變。” 當我們年老時，認知力的下降自然而然會發生進而引發疾病，例如阿茲海默症。然而，根據一些研究發現，在2009維也納舉辦的阿茲海默症國際研討會(ICAD)所發表的結果顯示，omega-3脂肪酸營養補充品對已患有阿茲海默症的患者並沒有幫助。一些科學家和Martek公司更進一步的指出DHA對輕度到中度的阿茲海默症患者並沒有很具體的影響。“這份研究顯示出對阿茲海默症患者來說，在疾病初期食用海藻DHA會有顯著的改善。” 在為期六個月的DHA補充下，患有年齡相關性記憶缺損(ARCD)的老年人記憶力有改善，並且降低了心跳頻率。 Omega-3 DHA boosts memory for healthy adults, not Alzheimer’s sufferersDaily supplements with the omega-3 fatty acid docosahexaenoic acid (DHA) may improve both memory function and heart health in healthy older adults, according to a new study from Martek. The results, specific to people with a decline in cognitive function that occurs naturally with age, were presented at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD 2009) in Vienna. Almost 500 people took part in the randomised, double-blind, placebo-controlled, multi-center, six month study, which also recorded improvements in the heart rate of people receiving the DHA supplement. The study was funded by Martek Biosciences. “In our study, healthy people with memory complaints who took algal DHA capsules for six months had almost double the reduction in errors on a test that measures learning and memory performance versus those who took a placebo,” said Yurko-Mauro, PhD, associate director of clinical research at Martek and lead researcher of the study. “The benefit is roughly equivalent to having the learning and memory skills of someone three years younger.” Cognitive decline occurs naturally as we age, and precedes diseases such as Alzheimer's. However, according to other findings also presented at ICAD 2009 in Vienna, the omega-3 fatty acid supplements did not benefit people already suffering from Alzheimer’s disease. Scientists from Oregon Health and Science University, the University of California, San Diego, Boston University, and Martek report that DHA had no general impact on the cognitive health of people with mild to moderate Alzheimer's. Implications “These two studies raise the possibility that [interventions] for Alzheimer's must be given very early in the disease for them to be truly effective,” said William Thies, PhD, chief medical and scientific officer at the Alzheimer's Association. “For that to happen, we need to get much better at early detection and diagnosis of Alzheimer's, in order to test therapies at earlier stages of the disease and enable earlier intervention,” he added. Alzheimer’s data The Alzheimer’s study involved 402 people with an average age of 76, ‘probable’ Alzheimer’s, dietary DHA intakes of no greater than 200 mg per day, and a Mini-mental state exam score (MMSE) between 14 and 26. The participants were randomly assigned to receive a daily DHA dose of 2 grams per day, or placebo, for 18 months. Results of the double-blind, randomised, placebo-controlled clinical trial, funded by the National Institutes of Health, showed no evidence for benefit in the studied population. Blood levels of DHA did increase, however. "These trial results do not support the routine use of DHA for patients with Alzheimer's," said lead researcher Joseph Quinn, MD. In a subset of people who carried the "e4" version of the "ApoE" gene, however, the researchers noted a slower rate of decline on the primary test of mental function (the ADAS-cog). ApoE-e4 is known to increase the risk of developing Alzheimer's but does not appear to modify the rate of disease progression. "This is an intriguing exploratory result," said Quinn. "However it must be treated with appropriate caution. The finding requires further study for confirmation." The golden touch on age-related cognitive decline The Memory Improvement with DHA Study (MIDAS) involved 485 healthy older people with an average age of 70 and a mild memory complaint. The participants were randomly assigned to receive either 900 mg per day of algal DHA or placebo for 6 months. Results of the randomised, double-blind, placebo-controlled, multi-centre study showed that participants taking DHA supplements made significantly fewer errors on the Paired Associate Learning (PAL) test compared to when they started the study. Furthermore, plasma DHA levels doubled during the study in the DHA group, and correlated with the PAL response. The researchers also noted a significant decrease in heart rate in the DHA group, while blood pressure and weight did not change. “Six month supplementation with DHA (900mg/d) improves memory function and decreases heart rate in healthy older adults with ARCD. This improvement on the PAL is associated with a shift in the normative distribution to a younger age,” wrote the MIDAS investigators. 資料來源: Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD 2009) in Vienna “Results of the MIDAS Trial: Effects of Docosahexaenoic Acid on Physiological and Safety Parameters in Age-Related Cognitive Decline”
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