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| 維他命D與代謝症候群 |
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維他命D與代謝症候群 血液中維他命D的濃度提高跟代謝症候群的罹患率有關係。 研究結果顯示，最低濃度的陽光維他命(維他命25D)跟代謝症候群的關聯比最高濃度的多了21%。學者發現到低維他命濃度並不會造成代謝症候群，並表示應該要針對”加強維他命D的服用會降低心血管疾病的危險因子”來做研究。 代謝症候群(MetS)是一種症狀，特徵為中央型肥胖，高血壓和不穩定的血糖和胰島素代謝。同時代謝症候群跟糖尿病二型與心血管疾病有關連。學者分析了257位男性與女性的維他命D在血液中的濃度還有飲食、營養補充品的服用，發現到維他命D的濃度跟高膽固醇密度脂肪膽固醇(HDL)的濃度有關。最值得注意的是，在研究結果顯示，血液中的維他命25D跟HDL的濃度有很大的關聯。每增加10ng/mL的維他命25D，就會提升3.8到4.2/dL的HDL濃度。這代表了每上升1mg/dL的HDL濃度就降低了4至6%的冠狀動脈心臟病(CHD)的危險因素。他們同樣的發現到維他命D濃度越高，三酸甘油脂的濃度、身體質量指數(BMI)，還有腰圍則越低。可能的解釋為因為維他命D是脂溶性的，所以比較容易被隱藏在脂肪組織下。所以在過度肥胖的人儲存維他命D的容量就比較大，因而降低了在血液循環系統中維他命25D的濃度。因此，在過度肥胖的病人則建議要提高比平常體重的人的維他命D的攝取量。
Low vitamin D levels linked to metabolic syndrome Increasing blood levels of vitamin D are linked to a lower prevalence of the metabolic syndrome, as well as improved ‘good’ cholesterol levels, says a new study.
According to findings published in the Journal of Clinical Lipidology, the lowest levels of the sunshine vitamin were associated with a 31 per cent prevalence of metabolic syndrome, compared to only 10 per cent for people with the highest average levels. The researchers noted that the results do not prove that low vitamin D levels contributes or causes metabolic syndrome, and called for more studies to “assess whether increasing vitamin D intake will improve the metabolic cardiovascular risk factor profile”. “Although previous surveys have also reported associations between low 25(OH)D concentration and metabolic syndrome components, to our knowledge, the present investigation is the first to report this finding in a sample with a high prevalence of vitamin D dietary supplement users in which frequencies of vitamin D insufficiency and deficiency were low,” wrote the researchers, led by Kevin Maki from Illinois-based Provident Clinical Research Metabolic syndrome (MetS) is a condition characterised by central obesity, hypertension, and disturbed glucose and insulin metabolism. The syndrome has been linked to increased risks of both type-2 diabetes and cardiovascular disease (CVD). Study details The researchers analysed vitamin D levels in the blood of 257 men and women aged over 18. Dietary and supplementary intakes were assessed using a food frequency and dietary supplement questionnaires, said the researchers. Their results showed that vitamin D blood levels were associated with HDL cholesterol levels. “The most notable finding from the present study was the strong relationship between serum concentrations of 25(OH)D and HDL-C concentrations,” wrote the researchers. “Each 10 ng/mL increment in 25(OH)D was associated with an increase of 3.8 to 4.2 mg/dL in HDL-C [...] This is of considerable potential importance given that each 1 mg/dL increment in HDL-C is associated with a 4 to 6 per cent reduction in coronary heart disease (CHD) risk.” They also observed inverse associations between vitamin D levels and triglyceride levels, body mass index, and waist circumference, meaning that higher vitamin D levels were associated with lower values for these measurables. Explanation “A potential explanation for our observation of an inverse association between 25(OH)D and indicators of adiposity (waist and body mass index) may be that vitamin D is fat soluble and is therefore easily sequestered in adipose tissue,” wrote the researchers. “Thus, there is a greater storage capacity for vitamin D in overweight and obese individuals, which may result in a reduced circulating concentration of 25(OH)D. “As a result, in order to maintain a given circulating 25(OH)D concentration, overweight and obese individuals may have to consume higher quantities of vitamin D than would be the case for normal weight populations,” they said. Source: Journal of Clinical Lipidology
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